Endocrine Abstracts

BACKGROUND: Healthy and Adult Growth Hormone Deficient (AGHD) women exhibit elevated leptin concentrations compared with men. AGHD is characterised by obesity and associated with increased leptin concentration and decreased leptin pulsatility, however the gender variation in rhythm and pulse parameters is yet to be defined. Following growth hormone replacement (GHR), leptin concentration decreases and pulsatility increases preceding a reduction in body fat mass (BFM).<p cl...

BACKGROUND: Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD). PTH plays an important role in bone metabolism and reports have suggested target cell insensitivity to PTH as a contributor to the changes in bone turnover seen in AGHD. Although growth hormone replacement (GHR) increases BMD, the underlying mechanisms remain unclear.OBJECTIVES: To determine the effect of GHR on 24-hour PTH profiles, phosphocalcium ...